At what age should individuals with Juvenile Polyposis Syndrome start undergoing endoscopy?

Individuals with Juvenile Polyposis Syndrome (JPS) are generally recommended to start undergoing endoscopic surveillance between the ages of 12 to 15 years. This recommendation is based on the understanding that the risk of developing gastrointestinal polyps and potential malignancies increases as individuals with JPS age, particularly in the colon and rectum.

Beginning endoscopy in the early teenage years allows for the timely detection and management of polyps, which can reduce the risk of gastrointestinal complications and cancer later in life. At this age, the digestive tract is sufficiently developed to tolerate the procedure, and any polyps present can be identified and treated appropriately to prevent progression to cancer. Regular monitoring thereafter is essential for individuals with JPS to maintain their health and manage their condition effectively.

Other choices are less appropriate because starting endoscopy at birth would be overly invasive with no immediate benefit, while waiting until ages 5-10 years or 18-20 years may miss the critical window for early detection and intervention of polyps, which is essential for managing the risks associated with this syndrome.