Hypohidrotic Ectodermal Dysplasia is associated with which of the following symptoms?

Hypohidrotic Ectodermal Dysplasia is a genetic condition characterized by the absence or reduced function of certain ectodermal structures, which can lead to a variety of clinical features. One of the hallmark symptoms of this condition is hypodontia, which refers to the congenital absence of teeth. Individuals with Hypohidrotic Ectodermal Dysplasia often have fewer teeth than normal, and those that do develop may be small or malformed. This dental anomaly stems from the abnormal development of the dental tissues, which are derived from the ectoderm.

The other symptoms mentioned are not typical of Hypohidrotic Ectodermal Dysplasia. Increased pigmentation and hyperhidrosis (excessive sweating) would not be associated with this condition; actually, individuals often experience decreased pigmentation in the skin and hair, and hypohidrosis (reduced sweating) due to issues with sweat gland development. Furthermore, while some individuals with various genetic disorders may experience intellectual disabilities, severe mental retardation is not a common association with Hypohidrotic Ectodermal Dysplasia itself. Therefore, hypodontia stands out as a defining characteristic of this condition.