In Langer-Giedion syndrome, what feature is likely to be observed alongside growth retardation?

For individuals with Langer-Giedion syndrome, progressive growth retardation is a hallmark feature of the condition. This genetic disorder is caused by deletions on chromosome 8, which can lead to various developmental issues. In affected individuals, growth retardation typically begins in infancy and can continue through childhood and adolescence, resulting in shorter stature compared to their peers.

Progressive growth retardation signifies that the growth issues are not static but rather worsen over time, which can be a significant concern for families and healthcare providers. Recognizing this feature can aid in early diagnosis and monitoring for other associated health issues and developmental concerns.

While macroglossia, broad shoulders, and abnormal limb length profiles may present in some patients, they are not defining or consistently observed features of Langer-Giedion syndrome. In contrast, the progressive nature of growth retardation provides a clear understanding of the syndrome's impact on growth and development over time.