In the case of DiGeorge Syndrome, which organ system is most commonly affected by congenital heart defects?

DiGeorge Syndrome, also known as 22q11.2 deletion syndrome, is a genetic disorder that can affect various organ systems, but it is particularly known for its association with cardiovascular anomalies. The cardiovascular system is the most commonly affected organ system in this condition, leading to congenital heart defects. These defects frequently include conotruncal anomalies, such as tetralogy of Fallot, truncus arteriosus, and interrupted aortic arch.

The underlying genetic cause related to DiGeorge Syndrome impacts the development of certain structures during embryonic development, leading to these heart defects. Clinicians often screen for cardiac issues in individuals diagnosed with DiGeorge Syndrome, highlighting the priority of the cardiovascular system in the context of this condition.

The other organ systems listed—digestive, respiratory, and nervous—can also show abnormalities in patients with DiGeorge Syndrome, but they are not as closely associated with congenital heart defects as the cardiovascular system is.