In which syndrome is midface retrusion NOT accompanied by underdevelopment?

Midface retrusion refers to a situation where the middle part of the face, including the nose and cheeks, is positioned further back than is typical. In the context of craniosynostosis syndromes, it is important to consider how this feature presents alongside other developmental characteristics.

Crouzon Syndrome is characterized primarily by craniosynostosis, where the sutures in the skull close prematurely, leading to a specific set of facial features including midface retrusion. However, unlike the other syndromes listed, this midface retrusion in Crouzon Syndrome is not typically associated with general underdevelopment of midfacial structures. Individuals with Crouzon Syndrome can exhibit a relatively normal development of the teeth and alveolar bone, despite the change in midface positioning.

In contrast, other syndromes mentioned tend to display midface retrusion along with more pronounced underdevelopment of related structures. For example, Apert Syndrome and Pfeiffer Syndrome involve more severe morphological changes that often include both retrusion and underdevelopment. Carpenter Syndrome also shows a combination of underdevelopment with midface implications.

Therefore, Crouzon Syndrome is the condition where midface retrusion occurs without the notable underdevelopment that is found in the other syndromes listed, making it a