Neurofibromatosis 2 is commonly associated with which tumor type?

Neurofibromatosis type 2 (NF2) is primarily associated with vestibular schwannomas, which are benign tumors that typically arise from the Schwann cells of the vestibulocochlear nerve (cranial nerve VIII). These tumors are characterized by bilateral occurrence in individuals with NF2, which distinguishes them from other types of tumors.

Patients with NF2 often present with hearing loss, tinnitus, and balance issues due to the pressure exerted by the tumors on the surrounding structures. The genetic basis for NF2 involves mutations in the NF2 gene located on chromosome 22, which encodes the protein merlin, a tumor suppressor. When this gene is dysfunctional, there is a loss of control over cell growth, leading to the formation of schwannomas, particularly affecting cranial and spinal nerves.

Other tumor types listed, such as dermatofibroma, chondroma, and glioma, are not characteristically associated with neurofibromatosis type 2. Dermal tumors like dermatofibromas typically arise sporadically and are not linked to NF2. Chondromas arise from cartilaginous tissue and are generally unrelated to neurofibromatosis. Gliomas, the tumors