What are some symptoms of FXTAS in individuals with Fragile X premutation?

The identification of ataxia and Parkinson's-like features as symptoms of Fragile X-associated tremor/ataxia syndrome (FXTAS) in individuals with the Fragile X premutation is well-supported by clinical research. FXTAS typically manifests in older male carriers of the Fragile X premutation and is characterized by neurological symptoms that can include tremors, balance issues (ataxia), and cognitive decline.

Ataxia refers to a lack of voluntary coordination of muscle movements, which can affect gait and stability. The Parkinson's-like features that can develop in patients with FXTAS include bradykinesia (slowness of movement), resting tremors, and rigidity. These symptoms arise due to neurodegeneration caused by the buildup of abnormal proteins associated with the premutation alleles.

Other choices provided present symptoms that are not characteristic of FXTAS. Seizures and microcephaly are typically associated with Fragile X syndrome due to the full mutation, rather than FXTAS. Ovarian failure before age 30 is more applicable to females with the Fragile X premutation but does not relate to FXTAS, which primarily affects males. Spasticity and tremors may occur in other conditions but