What chromosomal alteration is usually associated with Miller-Dieker Syndrome?

Miller-Dieker Syndrome is most commonly associated with a deletion on chromosome 17, specifically at the 17p13.3 region. This genetic condition is characterized by lissencephaly, which is a brain malformation, along with other physical anomalies and developmental delays. The deletion affects the LIS1 gene, which is crucial for proper brain development. Understanding the specific chromosomal alterations associated with various syndromes is vital for genetic counseling, as it helps in the identification of the condition in affected individuals and guides appropriate management and support.

The other options relate to different syndromes or genetic conditions, not linked specifically to Miller-Dieker Syndrome, which reinforces the importance of accurately identifying the relevant chromosomal alterations in genetic counseling practices.