What genetic anomaly is associated with Wolf-Hirschhorn syndrome?

Wolf-Hirschhorn syndrome is associated with a deletion on the short arm of chromosome 4, specifically at the 4p16.3 region. This genetic anomaly leads to a range of characteristic clinical features, including developmental delay, distinctive facial features, and seizures. The deletion disrupts critical genes involved in development, which accounts for the severity and variety of symptoms seen in affected individuals.

The significance of the chromosome 4 deletion in Wolf-Hirschhorn syndrome is critical for diagnosis and genetic counseling. It provides insight into the genetic basis of the condition, informing management strategies and potentially guiding treatment options. The other chromosome deletions listed do not correspond to Wolf-Hirschhorn syndrome; each of those conditions is associated with different syndromes or clinical presentations.