What is a characteristic sign of Cockayne Syndrome?

Cockayne Syndrome is a genetic disorder characterized by the body’s inability to adequately repair DNA damage, primarily affecting growth and development. A hallmark feature of Cockayne Syndrome is sensitivity to sunlight, also known as photosensitivity. Individuals with this condition often exhibit a range of symptoms upon exposure to sunlight, including skin damage, which underscores the necessity for protection from ultraviolet light.

This sensitivity is particularly important in Cockayne Syndrome because it reflects the underlying cellular mechanisms of the disorder. The impaired DNA repair pathways not only affect the skin but also contribute to other systemic manifestations associated with the syndrome.

In contrast, while other choices might describe aspects of genetic disorders broadly, they do not specifically relate to the hallmark symptoms of Cockayne Syndrome. For instance, decreased fertility, a butterfly rash, and short stature are associated with different conditions or syndromes, but none are defining features associated with Cockayne Syndrome. Understanding the specific manifestations of this syndrome, particularly photosensitivity, is crucial for diagnosis and management.