What is a common feature of Cardio-Facial-Cutaneous Syndrome?

Cardio-Facial-Cutaneous Syndrome (CFCS) is characterized by a distinctive combination of clinical features, and one of the hallmark traits is the presence of coarse facial features. Individuals with CFCS often exhibit a broad forehead, downturned eyes, a prominent nasal bridge, and thick lips, contributing to the coarse appearance of their facial characteristics.

This syndrome also includes a range of cardiovascular, dermatological, and developmental abnormalities, but the distinctive facial features are one of the most recognizable aspects that help in identifying the condition. The other characteristics of CFCS can vary widely among affected individuals and may not be as defining as the coarse facial features. For instance, while short neck and excess skin, low-set ears, and possibly metabolic abnormalities can occur in other syndromes or conditions, coarse facial features are more consistently associated with CFCS and play a critical role in its clinical diagnosis.