What is one major symptom of Zellweger Syndrome?

One major symptom of Zellweger Syndrome is feeding difficulties. This condition is a result of peroxisomal biogenesis disorders and often leads to various metabolic issues due to impaired lipid metabolism. Infants with Zellweger Syndrome typically present with significant feeding challenges due to various factors, including gastrointestinal dysmotility, poor muscle tone, and the overall severity of their condition, which can affect their ability to coordinate suck and swallow.

The other symptoms listed, such as muscle weakness, cardiac hypertrophy, and chronic cough, can indeed occur in patients with Zellweger Syndrome but are not as specific or prominent as the feeding difficulties. Muscle weakness is a common finding in many genetic conditions, and while cardiac issues can arise, they are not as universally noted as feeding problems in these patients. Chronic cough could be associated with various respiratory issues, but it is not characteristically linked to Zellweger Syndrome. Feeding difficulties are integral to the clinical picture and can significantly impact the infant's nutritional status and overall prognosis.