What is the approximate recurrence risk of any given multifactorial condition with one affected distant relative (2nd-3rd degree)?

The recurrence risk of multifactorial conditions is significantly influenced by the degree of relatedness to affected individuals in a family. When assessing the risk for conditions that have a multifactorial inheritance pattern, the risk tends to be lower when the affected individual is more distantly related, such as a second or third-degree relative.

With one affected distant relative, the approximate recurrence risk is typically estimated to be about 1%. This low percentage reflects the combination of genetic predisposition and environmental influences characterizing multifactorial disorders. The risk is often quantified in the range of 1-5%, depending on various factors, including the specific condition and the population studied.

In contrast, the other answer choices suggest higher recurrence risks, which is generally not seen with just one affected distant relative. Thus, the correct understanding of the recurrence risk in this context supports that an estimated risk of about 1% is appropriate for multifactorial conditions involving a second or third-degree relative.