What is the approximate recurrence risk of any given multifactorial condition with one affected first-degree relative?

When considering the recurrence risk of a multifactorial condition with one affected first-degree relative, the approximate risk is indeed within the range of 2-5%. Multifactorial conditions are influenced by multiple genes as well as environmental factors, making the inheritance pattern complex.

Having a first-degree relative who is affected increases the likelihood of developing the same condition compared to the general population, but because multifactorial diseases are not determined by a single gene, the recurrence risk remains moderate rather than high. This risk reflects the complex interplay of genetics and environment that characterizes multifactorial conditions, so while there is an elevated recurrence risk, it does not approach the higher percentages associated with single-gene disorders.

Understanding this concept is crucial in genetic counseling, as it helps in providing families with accurate information about their risk, guiding them in their reproductive decisions and management of health.