What is the carrier frequency of Alpha Thalassemia in the Asian and Middle Eastern populations?

The carrier frequency of Alpha Thalassemia, particularly in Asian and Middle Eastern populations, has been estimated to be approximately 1 in 20. This reflects a significant prevalence in these regions compared to other parts of the world due to various factors including historical factors such as malaria and population genetics.

In these populations, Alpha Thalassemia frequently occurs because carriers typically have a selective advantage against malaria. This genetic adaptation has led to a higher frequency of the gene variants responsible for the condition. As a result, screening and awareness programs in these regions continue to emphasize the importance of understanding this carrier status, especially in family planning and prenatal care contexts.

While other frequencies presented in the options may pertain to different population groups or types of thalassemia, the carrier frequency of 1 in 20 specifically highlights the significant prevalence of Alpha Thalassemia among Asian and Middle Eastern populations. Hence, this figure aligns with established epidemiological data in the field.