What is the carrier frequency for Beta Thalassemia in Mediterranean populations?

The carrier frequency for Beta Thalassemia in Mediterranean populations is indeed approximately 1 in 20. This relatively high carrier frequency can be attributed to the historical prevalence of malaria in these regions. Individuals who are carriers of the Beta Thalassemia trait often have a selective advantage in malaria-endemic areas, which has led to an increased frequency of the mutation within the population over generations.

Understanding carrier frequencies is essential for genetic counseling, as it informs healthcare providers and patients about the risk of offspring being affected by genetic conditions like Beta Thalassemia. For populations in the Mediterranean, the prevalence means that it is important for individuals considering family planning to be aware of their carrier status and that of their partners to make informed reproductive choices.