What is the inheritance pattern of Von Willebrand disease?

Von Willebrand disease (VWD) primarily exhibits an autosomal inheritance pattern, particularly autosomal dominant. This means that the disorder can be passed down from just one affected parent to the offspring, and individuals with the condition typically display some degree of bleeding risk due to deficiencies or dysfunction of von Willebrand factor.

The classification of von Willebrand disease into different types, specifically Type 1 (mild), Type 2 (moderate), and Type 3 (severe), reinforces that while Type 1 and Type 2 are generally inherited in an autosomal dominant manner, Type 3 can occur in an autosomal recessive pattern since there can be two copies of the mutated gene in affected individuals. This variability supports the understanding that VWD can be seen in both autosomal dominant and recessive forms.

Therefore, recognizing that the inheritance of VWD includes both autosomal dominant and recessive components provides a comprehensive view of how this genetic disorder may manifest across different individuals and families.