What is the normal range for Fragile X syndrome?

The correct range for normal FMR1 gene repeats associated with Fragile X syndrome is indeed 5-44 repeats. Individuals with this range are considered to have a "normal" allele, which means they typically do not exhibit any symptoms of Fragile X syndrome. This allelic range is important in genetic counseling, as it helps to distinguish between those who are unaffected and those who may be carriers or at risk of passing on the condition.

Repeats in the FMR1 gene that fall within the range of 45-54 indicate a premutation status. Individuals with this premutation can be carriers of the syndrome, and they may experience some potential health issues, but they do not usually manifest the full clinical features of Fragile X syndrome, which arise in individuals with more than 200 repeats. Thus, the understanding of repeat ranges is critical for accurate diagnosis, management, and family planning in individuals potentially affected by Fragile X syndrome.