What is the primary cause of morbidity associated with SDHB mutations?

The primary cause of morbidity associated with SDHB mutations is indeed the development of head and neck tumors. SDHB (succinate dehydrogenase subunit B) mutations are part of a group of genetic alterations that can lead to hereditary paraganglioma-pheochromocytoma syndrome. While these mutations can increase the risk for pheochromocytomas, which are tumors of the adrenal gland, they are particularly associated with paragangliomas, which can occur in various locations in the head and neck.

These head and neck tumors can result in significant morbidity due to their potential for local invasion, affecting critical surrounding structures, causing symptoms related to their location, and the need for surgical intervention. Frequent surveillance and management of these tumors are often critical components of care for individuals with SDHB mutations, given their impact on quality of life and health outcomes.

In contrast, while pheochromocytomas and other options might present risks associated with SDHB mutations, the emphasis on head and neck tumors captures the unique challenges faced by individuals with these mutations, marking it as the primary concern for morbidity.