What is the recurrence risk for Cleft Lip/Cleft Palate with one affected first-degree relative?

The recurrence risk for cleft lip and/or cleft palate when there is one affected first-degree relative is approximately 2%. This figure is derived from epidemiological studies that have investigated the heritability and familial recurrence patterns of these congenital conditions.

When assessing the risk, it's important to note that having a first-degree relative, such as a parent or sibling, significantly increases the likelihood of occurrence compared to the general population risk, which is about 0.5% to 1%. The 2% estimate is a critical figure in genetic counseling, as it helps families understand their potential risks and informs them about the multifactorial nature of the condition, which involves both genetic predispositions and environmental factors.

The other values do not accurately reflect the standard risk associated with having one affected first-degree relative for this condition based on current genetic understanding and clinical data.