What is the recurrence risk for nonsyndromic deafness if there is one affected first-degree relative?

The recurrence risk for nonsyndromic deafness in the presence of one affected first-degree relative is generally estimated to be around 5% if the affected relative is a sibling. This figure reflects the polygenic and multifactorial nature of nonsyndromic hearing loss, where the overall risk of recurrence is influenced by the genetic background, the inheritance pattern, and environmental factors.

In families with an affected sibling, the risk estimate aligns with the typical recurrence risks noted in studies of nonsyndromic deafness, considering that siblings share approximately 50% of their genes. This risk can vary based on the specific genetic and environmental context of the family, but 5% is a widely accepted estimate.

In contrast, having an affected parent may suggest a greater likelihood of inheritance, but the exact recurrence risk can differ based on the specific genetic factors involved. Other answer choices may suggest higher numbers that do not accurately reflect the established recurrence risks observed in clinical practice. Thus, the selected answer accurately represents the commonly accepted risk for siblings in the context of nonsyndromic deafness.