What major physical feature is commonly observed in individuals with Cornelia de Lange Syndrome?

Individuals with Cornelia de Lange Syndrome (CdLS) are known to exhibit a range of distinctive facial features, which is a hallmark characteristic of this condition. These facial features typically include arched eyebrows, long eyelashes, a short nose, and a thin upper lip. The uniqueness of these traits often aids in the clinical diagnosis of the syndrome. The distinct appearance associated with CdLS is a reflection of the genetic alterations that affect growth and development, leading to the recognizable physical manifestations that set this condition apart from others.

While short stature and wide-set eyes may also be observed in individuals with CdLS, they are not as definitive or characteristic as the distinctive facial features. Long limbs is not typically associated with CdLS; in fact, individuals with the syndrome often have shorter stature and proportionally shorter limbs. Hence, the key identifiers of Cornelia de Lange Syndrome lie in the distinctive facial characteristics, making this answer the most accurate representation of the syndrome's physical manifestations.