What medication should be avoided in individuals with Brugada Syndrome?

In individuals with Brugada Syndrome, the use of first-generation antihistamines should be avoided due to their potential to exacerbate the condition. Brugada Syndrome is associated with a high risk of sudden cardiac arrest caused by ventricular arrhythmias, and certain medications can provoke these dangerous rhythms.

First-generation antihistamines can cause significant sedation and have anticholinergic effects, which may lead to increased risk of arrhythmia in susceptible individuals. These medications can also prolong the QT interval, further increasing the risk of life-threatening arrhythmias.

In contrast, beta-blockers and quinidine have specific uses in the management of Brugada Syndrome and can be employed in some patients to reduce arrhythmias. ACE inhibitors do not have a direct relationship with the pathophysiology of Brugada Syndrome and do not pose the same risk as first-generation antihistamines. Therefore, avoiding first-generation antihistamines is crucial for the safety of individuals with Brugada Syndrome.