Which cancer is commonly associated with Beckwith-Wiedemann Syndrome?

Beckwith-Wiedemann Syndrome (BWS) is a genetic condition that predisposes individuals to several growth-related abnormalities, including an increased risk for specific types of tumors. Wilms tumor, which is a kidney cancer primarily affecting children, is particularly associated with BWS. This syndrome features empirical evidence suggesting that children with BWS have a significantly higher risk of developing Wilms tumor compared to the general population.

The other cancers mentioned, such as leukemia, neuroblastoma, and breast cancer, do not have as strong an association with Beckwith-Wiedemann Syndrome as Wilms tumor does. While individuals with BWS might have risks for other malignancies, the association with Wilms tumor is the most clinically significant and well-documented in the literature regarding this syndrome. Understanding this relationship is crucial for genetic counselors and healthcare providers in monitoring and managing the health of individuals with BWS.