Which chromosome numbers are classified as acrocentric in humans?

The classification of chromosomes as acrocentric in humans refers to their structure, specifically the position of the centromere. Acrocentric chromosomes have the centromere located close to one end, resulting in one long arm and one short arm. In humans, the acrocentric chromosomes include chromosomes 13, 14, 15, 21, and 22. These chromosomes are significant for various genetic conditions, as they often contain ribosomal RNA genes and can play a role in certain chromosomal rearrangements or syndromes.

Understanding the significance of acrocentric chromosomes is essential in genetic counseling, as these chromosomes can be involved in conditions such as Robertsonian translocations, which can lead to aneuploidies or other genetic syndromes. The identification of acrocentric chromosomes also aids in interpreting karyotypes and understanding inheritance patterns associated with the genes they carry.