Which condition has symptoms of aggression and sleep disorders along with neurological decline?

Sanfilippo Syndrome, also known as mucopolysaccharidosis III (MPS III), is a rare genetic disorder caused by the body's inability to properly break down heparan sulfate due to deficiencies in specific enzymes. This condition leads to the accumulation of toxic substances in various tissues, particularly affecting the nervous system.

Individuals with Sanfilippo Syndrome often exhibit a range of symptoms including behavioral issues like aggression and hyperactivity, as well as significant sleep disturbances. Neurological decline is also a hallmark of this condition, as it progressively affects cognitive function and motor skills over time. Children with Sanfilippo Syndrome may experience developmental delays, loss of previously acquired skills, and other neurological symptoms, which contribute to the overall decline in their neurological health.

The combination of these symptoms makes Sanfilippo Syndrome particularly distinct when compared to the other mentioned conditions. Each of the other syndromes presents with a variety of symptoms, but none specifically outline the triad of aggression, sleep disorders, and neurological decline in the same way as seen in Sanfilippo Syndrome.