Which condition is NOT associated with cafe au lait spots?

The chosen answer is correct because Marfan syndrome is not typically associated with café au lait spots. Marfan syndrome is a connective tissue disorder characterized by features such as tall stature, long limbs, scoliosis, and cardiovascular issues, rather than skin manifestations like café au lait spots.

In contrast, the other conditions listed are indeed associated with café au lait spots. Bloom syndrome is a genetic disorder linked to growth deficiencies and a predisposition to cancer, often presenting with café au lait spots. McCune-Albright syndrome, a disorder caused by postzygotic mutations, features café au lait spots as one of its hallmark findings along with hormonal abnormalities and skeletal changes. Noonan syndrome also can show café au lait spots among its diverse clinical features, which include short stature and congenital heart defects.

Understanding the associations of café au lait spots with these conditions is critical for accurate diagnosis and management in genetic counseling.