Which feature is characteristic of Type 1 Osteogenesis Imperfecta?

Type 1 Osteogenesis Imperfecta (OI) is characterized by several distinct features, one of which is the presence of blue sclerae and a tendency for moderate fractures. This condition results from a defect in collagen type I, leading to decreased bone density and strength. Individuals with Type 1 OI typically experience fractures with less trauma than would be expected, but the fractures are generally not as severe as those seen in other types of OI, such as Type 2, which can be perinatally lethal.

The blue sclerae occur due to the thinness of the collagen in the sclera, allowing the underlying choroidal pigmentation to show through. While individuals with Type 1 can sustain multiple fractures throughout their lives, the severity and frequency are less than in the more severe forms of osteogenesis imperfecta.

In contrast to this, the other options listed point to characteristics of differing types of OI or other conditions entirely. Perinatally lethal fractures are associated with Type 2 OI, which is much more severe and often results in early death. Short proximal long bones may be observed in various forms of skeletal dysplasia but are not a hallmark of Type 1 OI. A cleft palate, although it