Which genetic disorder has a high incidence of plexiform neurofibromas?

The genetic disorder associated with a high incidence of plexiform neurofibromas is Neurofibromatosis type 1 (NF1). Plexiform neurofibromas are benign tumors that can develop from multiple nerve fibers and are characteristic of NF1, affecting almost half of the individuals with this condition. These tumors can be present at birth or develop during childhood, and they typically present as soft, ill-defined masses on the skin or deeper in the tissue.

Neurofibromatosis type 2 (NF2) is primarily associated with bilateral vestibular schwannomas and does not typically feature plexiform neurofibromas. Legius syndrome, while also associated with neurofibromas, generally does not involve plexiform variants to the same extent seen in NF1. Emery-Dreifuss Muscular Dystrophy, a muscular dystrophy with a distinct genetic background, has no association with neurofibromas. Therefore, the strong correlation of plexiform neurofibromas with Neurofibromatosis type 1 makes it the correct choice in this context.