Which genetic syndrome commonly leads to both germline and somatic mutations impacting multiple organ systems?

Von Hippel-Lindau Syndrome is associated with mutations in the VHL gene, which contributes to a variety of tumors and cysts affecting multiple organ systems. This syndrome typically manifests through both germline mutations, which are inherited and present in the egg or sperm, and somatic mutations that occur in non-germline tissues throughout an individual’s life.

Individuals with Von Hippel-Lindau Syndrome may develop a range of conditions, such as hemangioblastomas (vascular tumors typically found in the brain and spine), renal cell carcinoma, and pancreatic neuroendocrine tumors. The presence of these tumors across different organ systems underscores the multi-faceted impact of both types of mutations.

In comparison, while Retinoblastoma primarily affects the eyes and can also have some systemic implications if associated with the hereditary form, it is less broadly systemic in its mutation effects compared to Von Hippel-Lindau Syndrome. Gorlin Syndrome, also known as Basal Cell Nevus Syndrome, primarily involves skin, jaw, and central nervous system tumors but doesn’t have the same widespread implications across different organ systems. Pheochromocytoma typically refers to tumors of the adrenal gland itself and doesn't encompass the broader spectrum of organ systems like Von Hippel