Which genetic syndrome is characterized by both intellectual disability and broad thumbs?

Rubstein-Taybi syndrome is characterized by both intellectual disability and distinct physical features, including broad thumbs. Individuals with this genetic disorder often present with various developmental issues, leading to cognitive impairments. The broad thumbs and toes are hallmark features that help distinguish Rubstein-Taybi syndrome, which results from mutations in the CREBBP or EP300 genes. This syndrome also encompasses other features such as facial dysmorphism and cardiac anomalies, but the combination of intellectual disability and broad thumbs is particularly significant in its diagnosis.

Other genetic syndromes mentioned may involve intellectual disability or physical manifestations but do not specifically exhibit both the noted cognitive impairment and broad thumbs in conjunction. Therefore, the emphasis on these two specific clinical traits makes Rubstein-Taybi syndrome the appropriate answer.