Which is a key identifying feature of Muir Torre Syndrome?

Muir-Torre Syndrome is characterized by the presence of both sebaceous gland tumors and internal malignancies, particularly associated with mismatch repair gene mutations. The sebaceous gland tumors commonly found in this syndrome include sebaceous adenomas, sebaceous carcinoma, and keratoacanthomas. These tumors are a key identifying feature of the syndrome and are often among the earliest manifestations that lead to diagnosis.

In contrast, although hamartomatous polyps, nevi, and biliary tumors may be seen in other genetic syndromes or conditions, they are not defining characteristics of Muir-Torre Syndrome. Hamartomatous polyps are typically associated with conditions like Peutz-Jeghers syndrome or Juvenile Polyposis syndrome. Nevi are common skin lesions that do not specifically indicate genetic syndrome. Biliary tumors, while serious, are not a hallmark of Muir-Torre Syndrome. Hence, the association of sebaceous gland tumors with this condition is what distinctly identifies Muir-Torre Syndrome.