Which statement is true about Factor V Leiden thrombophilia?

The statement regarding Factor V Leiden thrombophilia that is true is that homozygous individuals have a higher risk of thrombosis than heterozygous individuals. Factor V Leiden is a mutation in the Factor V gene, which leads to resistance to activated protein C, a natural anticoagulant. This resistance increases the tendency for abnormal clotting, or thrombosis.

In individuals who are heterozygous for the mutation, there is an increased risk of venous thromboembolism, but in homozygous individuals, the risk is significantly higher due to the increased amount of mutated factor present in their system. This genetic predisposition to abnormal clotting is the hallmark of Factor V Leiden, and understanding the difference in risk levels between heterozygous and homozygous states is important for assessing an individual's risk for venous thrombotic events.

This emphasis on clotting disorders, as opposed to bleeding disorders, also clarifies the significant implications of the mutation. The other options listed do not align with the nature of Factor V Leiden. For example, it is not caused by vitamin K deficiency, nor does it follow an autosomal recessive inheritance pattern; it is an autosomal dominant condition. Additionally, the condition is associated with an increased